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IM Administration: Treatment of Tuberculosis: For adults, usually a daily dose of 2 g (potency) kanamycin is administered by IM injection in 2 equally divided doses (morning and evening) twice a week. Otherwise, 1 g (potency) once daily is administered 3 days a week. Kanamycin Sulphate Meiji should be locally applied when necessary.
Kanamycin sulphate Meiji 0.5-0.75 g (potency) is, however, administered as a single dose to elderly patients (>60 years). The dose should be decreased for children and patients with a very small body weight.
In principle, Kanamycin Sulphate Meiji should be used in combination with other antituberculous drugs.
Other Infections: Usually, a daily dose of 1-2 g (potency) kanamycin is injected IM to adults in 1 or 2 equally divided doses. For children, 30-50 mg (potency)/kg of body weight daily is injected IM in 1 or 2 equally divided doses.
Local application should be conducted when necessary.
The dose may be adjusted according to the age of patients and severity of symptoms.
Local Injection: For lymph node tuberculosis, local injection is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 6 mL of Water for Injection and about 0.7 mL [100 mg (potency)] of the solutions at a time SC injected into the chin or upper sternocleidomastoid for the injected site.
Inhalation Therapy: It is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 9.2 mL of water for injection, and 1-3 mL of the solutions is given 1-3 times a day with a nebulizer.
Ear Bath: For stubborn, chronic, purulent otitis media, ear bath is effective in combination with IM administration. In this case, 1 g (potency) is dissolved in 5 mL of Water for Injection and 0.6 mL [100 mg (potency)] of the solutions at a time are given by the usual ear bath.